Natural therapies are gaining scientific and clinical traction as complementary approaches in oral medicine, marking a new era in treatment strategies. This lecture focuses on evidence-based natural agents including amino acids (L-arginine and L-glutamine), medical-grade honeys (thyme and Manuka), phytochemicals (e.g., curcumin, aloe vera), and probiotics that target conditions such as recurrent aphthous stomatitis, mucositis, candidiasis, and periodontal disease. Emphasis is placed on their mechanisms of action (antimicrobial, anti-inflammatory, and mucosal healing), comparative efficacy with conventional treatments, and practical integration into clinical protocols. Considerations surrounding standardization, safety (e.g., in diabetic patients), and current evidence gaps are critically examined.

Objectives:

• The clinical applications of selecting natural agents in oral medicine
• How these therapies work at a mechanistic level
• Evidence supporting their efficacy and safety
• Protocols for integrating them into patient care
• Key limitations and future research directions

Results:

1. Regular use of 20% thyme honey mouth rinse for one month proved its efficacy as a topical salivary stimulant reducing subjective symptoms and severity of xerostomia due to polypharmacy and improving the patient’s quality of life.

2. No adverse effects of regular use of thyme honey mouth rinse were reported ensuring its safety.